Collagen

• The word ‘collagen’ is derived from the Greek word ‘kola,’ meaning glue-producing in French word, Collagene.
• Collagen is a protein made of amino acids that provides structure, support and strength throughout the body. It’s a building block for bones, skin, hair, muscles, tendons and ligaments.
• Collagen is a fibrous protein, rich in proline and glycine
• It’s a vital part of connective tissue and is highly essential to hold body cells together. Collagen is one of the best possible sources of all essential amino acids.
• Collagen helps replace dead skin cells and reduce blood clots.
• Collagen decreases with age, sun damage, and smoking. Collagen supplements are derived from fish and bovine .

Chemical formula: C4H6N2O3R2. (C7H9N2O2R)n

CAS Number: 9007-34-5

Functions of Collagen:

• Collagen is rigid and resistant to stretching for skin also provides strength and elasticity
• Collagen interacts with directly with cells in at least three distinctive ways.
• Interact receptors that recognise an Arg-Gly-Asp-Thy sequence
• Through adhesive proteins such as fibronectin and laminin
• Via proteoglycans
• Provides flexibility, support and movement to Cartilage
• Strength, Support, Shape and elasticity to the tissues.
• Collagen Fills the Sclera of the eye in crystalline form
• Collagen protects the delicate organs like kidneys and Spleen

Health benefits of Collagen:

1. Support skin Health:

• Healthy collagen levels impact the elasticity, hydration and integrity of the skin. Studies have confirmed that the intake of collagen supplements helps in maintaining the elasticity of the skin and prevent the ageing process.
• Collagen encourages the growth of fibroblasts which enhances collagen production in the body

2. Benefits of the Joints::

• Collagen is a crucial component to maintain cartilage structure and integrity. Studies have shown that collagen supplements helps in relieving the symptoms of osteoarthritis and joint pains.
• Scientists have inferred that supplemental collagen accumulate in cartilage and stimulate the tissues to make collagen

3. Boost Gut health:

• High levels of proline,glycine and glutamine in collagen benefits the intestine and stomach.
• The strength of gut lining is maintained by these amina acids.
• Collagen supplements helps in preventing symptoms of leaky gut syndrome

4. Promotes Heart Health:

• Arteries that carry blood from the heart to other body parts and tissues.
• The structure of arteries depends on collagen with the decline in collagen levels.
• The arteries become weak which may lead to atherosclerosis. studies have shown the collagen supplements has significantly reduced artery stiffness there by reducing the risk of atherosclerosis.

5. Improves the muscle mass:

• Muscle tissue comprises 10% collagen which helps maintain the function the function and strength of the muscle.
• Glycine an amino acid present in collagen enhances the level of creative a crucial muscle protein.
• Muscle mass is maintained by collagen by reducing muscle breakdown
• Collagen supplements helps in boosting muscle mass in people who lost muscle mass as they aged.

6. Prevent bone loss:

• Akins to tendons and ligaments, collagen is the key component of bones.
• Collagen provides structure to the bones and greatly contributes to bones density and strength.
• Osteoporosis is the result of bone loss and collagen supplements prevent the bone loss.

The collage can be divided into two groups .Fibrilar collagen and Non-Fibrillar Collagen

Types of collagen:

• Various types of collagen are found. The most common collagen, Type-I and Type-II.

Type-I Collagen:

• Type-I collagen gives strength to your skin,bones,ligaments and tendons
• Marine collagen is a type-I collagen.
• Marine collagen also known as Fish collagen that comes from the skin, and scales of fish.
• Marine collagen is rich in antioxidants and protects the skin from oxidation and aging.

Chemical structure of Type-I collagen

Functions of Type-I collagen:

• Type-I collagen is provides structure to tendons and ligaments.
• Skin elasticity, strength and anti-aging.
• Type-I collagen is essential when it comes to the beauty benefits.

Applications of Marine/Fish Collagen:

• Dermis regeneration
• Heart muscle reconstruction
• Promote polarity nerve cells, alignment and increase adhesion

Uses of Marine/Fish Collagen:

a) Healthier skin:

Marine collagen helps to increase skin moisture and also protect harmful effects of UV exposure and photo aging

b) Reduce wrinkle:

Marine collagen rebuilds the tissues to increase skin elasticity and reduce the wrinkles

c) Biotin:

Marine collagen helps in strong nails and healthy Hair.

d) Healthy Diet:

Marine collagen contains high in amino acids. It also contains additional nutrients and proteins that are essential for maintaining a balanced diet

Type-II Collagen:

• Type-II collagen is a fibrillar Collagen.
• Collagen type-II is original from Bovine collagen and chicken collagen.
• Bovine collagen is a naturally occurring protein found in bovine cartilage
• It makes the flexible cartilage that helps support your joints
• Collagen peptide Type-II also known as Hydrolyzed Type-II Collagen.
• It is a protein, derived from animal Cartilage that has been breakdown into peptides through enzymatic hydrolysis.
• These peptides are highly digestible and bio available.

Chemical structure of Type-II collagen:

Functions of Type-II collagen:

• Bovine collagen peptide Type-II collagen is highly bioactive and bio available
• It makes flexible cartilage ,Protection of bones at the joints
• They reduces inflammation in the synovial fluid
• Type-II collagen provides cushions joints, enabiling smooth and easy movement, also supporting the health of joints.

Applications of Type-II Collagen:

• Cartilage regeneration
• It can help to build muscle mass
• It can support weight loss goals it can be used as food additives

Uses of Bovine Collagen Type-II:

a) Aging Skin Health:

• collagen peptide is a major component of skin, hair, nails
• Collagen peptide may improve skin in both texture and elasticity also improve skin hydration
• Collagen peptide supplements helps to support skin repair and regeneration and also improve the symptoms of aging skin

b) Gut health:

• Collagen peptide contains glycine and glutamine; these amino acids are maintaining a healthy gut wall.
• Bovine collagen can help repair microscopic holes in the gut lining, which can reduce symptoms of leaky gut and other digestive disorders

c) May help Osteoarthritis symptoms:

Bovine collagen may help treat Osteoarthritis and rheumatoid arthritis. It can lead to pain and stiffness in your hands, Knees and hips among other body parts

d) May improve Muscle health:

It plays an important role to grow, repair and rebuild the muscle. They are bio available form of supplemental protein in the market. It can support muscle strength and may promote the synthesis of muscles.

UNDENATURATED CHICKEN COLLAGEN TYPE-II:

The undenaturated form of type-II collagen (UC-II) a nutritional supplement is derived from Chicken Sternum Cartilage.

Collagen type-II is a fibril forming collagen. It is a found in supplements comes from chicken

UC-II to improve joint health and also help with OA (Osteoarthritis) and RA (Rheumatoid arthritis)

It is also used to strengthen bones, promote bone growth and wound healing reduce joint pain increasing joint mobility, reduce pain from surgery, back pain and neck pain

Functions of UC-II:

• Promote the repair and regeneration of joint cartilage
• Increase bone density
• Improve healing ability of fracture
• Joint nutrition, inhibit joint inflammatory cytokines, relieve joint pain
• Improve emergency response ability, explosive power, excellent sports nutrition food
• Lubricate joints
• Promote the repair, reconstruction and regeneration of Osteonecrosis of the Femoral Head

Applications:

• Undenatured chicken collagen type II is often associated with joint health and immune system modulation
• It is commonly used as a supplement to support joint function and alleviate conditions like osteoarthritis.

Uses of Undenaturated chicken Collagen Type-II:

a) Artery health:

It helps keep arteries flexible and elastic which may prevent atherosclerosis, a disease that can lead to heart attack and stroke.

b) Joint Health:

UC-II can help provide lubrication to joints, which can ease movement and relieve pain when people suffer from osteoarthritis, UC-II can help reduce pain and improve tolerance

c) Immunomodulatory Effects:

Undenatured collagen type II powder has been investigated for its immunomodulatory effects, potentially preventing the immune system from attacking joint tissues. This process may prevent the immune system from attacking the body’s collagen, particularly relevant in conditions where autoimmune responses affect joint tissues such as rheumatoid arthritis

d) Cartilage Protection

By promoting the synthesis of new collagen and proteoglycans, undenatured collagen may help protect and regenerate cartilage that cushions and protects the ends of bones within joints.